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KMID : 0361820090280010021
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Journal of the Korean Society of Medical Ultrasound
2009 Volume.28 No. 1 p.21 ~ p.26
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Preoperative Diagnosis of Extraglandular Invasion of Thyroid Papillary Carcinoma: High Resolution Sonography versus Multidetector Computed Tomography
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Choi Yoon-Jung
Kim Dong-Hoon
Hong Hyun-Pyo
Yun Ji-Sup
Kwag Hyon-Joo
Kook Shin-Ho
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Abstract
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Purpose: To compare the diagnostic efficacy of high-resolution sonography (HRS) and multidetector computed tomography (MDCT) in determining the presence of extraglandular invasion of thyroid papillary cancer and to define ultrasound (US) features of perithyroidal invasion that correlate with histopathological findings.
Materials and Methods: We prospectively evaluated extracapsular invasion in 177 thyroid cancer patients using both HRS and MDCT. Receiver operating characteristics (ROC) were assessed with a four-point confidence scale (0 = no extracapsular invasion;1 = possible invasion;2 = probable invasion;3 = definite invasion) by two reviewers for each imaging modality. Sensitivity, specificity, and accuracy were analyzed for each modality, along with interobserver variability.
Results: MDCT had a mean area under the ROC curve larger than that of HRS (HRS = 0.733, MDCT = 0.807, p < 0.05). HRS and MDCT were significantly different with regard to diagnostic sensitivity, specificity, and accuracy for extrathyroidal extension (p < 0.05; HRS = 75.7%, 66.1%, and 69.8%, respectively; MDCT = 86.7%,69.7%, and 76%, respectively). Interobserver reliability was greater for MDCT than for HRS (kappa value, 0.861 versus 0.429). The cutoff value used in HRS for estimating the status of perithyroidal invasion was 2.
Conclusion: HRS may be useful for preoperative investigation of thyroid papillary carcinoma extension, but it was inferior to MDCT because of lower diagnostic accuracy and lower interobserver reliability.
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KEYWORD
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Multidetector computed tomography, Thyroid cancer, Ultrasonography
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